What Mucomist is and what it is used for?
Acetylcysteine is a derivative of the amino acid, cysteine. Mucomist® DT contains Acetylcysteine 600 mg. Mucomist® DT (dispersible tablet) is a new pharmaceutical form that ensures optimum stability, rapid dissolution, maximal absorption, high bioavailability in a perfectly calibrated dosage. Mucomist® Respirator Solution contains 20% or 200 mg/ml Acetylcysteine and available as sterile, unpreserved solution (not for injection). The 20% inhalation solution is given by nebulization or by instillation intratracheally.
As Mucolytic in pulmonary disease: Respiratory tract disorders associated with excessive viscous mucous such as- chronic bronchopulmonary disease.
As an antidote for Paracetamol overdose: Acetylcysteine, administered orally, is indicated as an antidote to prevent or lessen hepatic injury which may occur following the ingestion of a potentially hepatotoxic quantity of Paracetamol.
As for diagnostic bronchial studies: Such as bronchograms, bronchospirometry, and bronchial wedge catheterization.
Before you take Mucomist
Acetylcysteine is contraindicated in those patients who are sensitive to it. Acetylcysteine should be given in caution in asthma patients.
Taking other medicines
After taking Acetylcysteine orally it increases the bioavailability of amoxicillin, but shows no effect on doxycycline and reduces the absorption of cefalexine. Acetylcysteine seems to increase the effects of nitroglycerin. Taking Acetylcysteine at the same time as activated charcoal might decrease how well it works for preventing poisoning.
Pregnancy and breast-feeding
Pregnancy Category- B (US FDA).
How to take Mucomist
Mucomist® DT: The dispersible tablet should be dissolved in 1/2 glass of water before use (preferably in the evening). The duration of treatment should be 5 to 10 days in the acute phase. It may be continued in the chronic state for up to 6 months or according to the advice of the physician.
As a mucolytic:
Adults: 600 mg daily as a single dose.
In Paracetamol overdose: Initially 140 mg/kg, followed by 70 mg/kg every 4 hours for an additional 17 doses.
Mucomist® Respirator Solution: The 20% solution may be diluted to a lesser concentration with either Sodium Chloride for injection, Sodium Chloride for inhalation, sterile water for injection, or sterile water for inhalation.
As a mucolytic:
Adult: 5-10 ml of 10% or 20% solution by nebulizer every 6-8 hr PRN.
Children: 1-11 months: 1-2 ml of 20% or 2-4 ml of 10% solution by nebulizer every 6-8 hr PRN. 12 months-11 years: 3-5 ml of 20% or 6-10 ml of 10% solution by nebulizer every 6-8 hr PRN. Below 12 years: 5-10 ml of 10/20% solution by nebulizer every 6-8 hr PRN.
Possible side effects
Generally, Acetylcysteine is well tolerated. However, mild effects such as nausea, headache, tinnitus, urticaria, stomatitis, rhinorrhoea, chills, fever, bronchospasm may be observed. Occasional cases of nausea and dyspepsia, rare cases of urticaria may be observed.
How to store Mucomist
Mucomist® Respirator Solution:
Do not contain an antimicrobial agent; hence, care must be taken to minimize contamination of the sterile solution. Store below 25o C, away from light. Keep out of reach of children.
Keep in a cool and dry place. Protect from light. Keep out of the reach of children.